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John H. Wolfe holds a VMD and PhD in Immunology from the University of Pennsylvania. His research focuses on gene transfer, stem cell engraftment, and genetic diseases, utilizing animal models to understand disease mechanisms in the central nervous system. He has expertise in gene therapy and the use of viral vectors for brain pathogenesis research. His work involves comparisons of promoters and properties of transduction in different cell types within specific brain regions. Wolfe's lab is also involved in developing new techniques for tracking gene expression and cell fate in live animals using MRI and PET imaging. He supervises rotation projects that encompass molecular design and engineering of vectors, gene regulation, and neurodegenerative research themes.
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