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John Zimmerman joins the Meinig School faculty in the summer of 2025. His work focuses on the interface between living and non-living systems, aiming to build models that enhance the understanding of fundamental structure-function relationships in the body. This includes employing computational tissue engineering approaches to recreate emergent tissue-scale phenomena, with particular interests in cardiac development, heart function, nanoparticle-cell interactions, and cardiomyopathies. His doctoral studies involved synthesizing inorganic semiconductors for biological applications, including the development of mechanical models to engineer intracellular force probes and studying nanoparticle transport through endocytosis pathways. His postdoctoral work at Harvard University’s School of Engineering and Applied Sciences was centered around building tissue-engineered models of the heart. This involved developing mechanical fluid-dynamic simulation software for studying the deformation of cardiac tissues over time and space, creating tissue-engineered systems to test predictions. His work is complemented by using machine-learning directed optimization approaches to provide insights into biological structure-function relationships, particularly how muscle tissue structures contribute to mechanical function.
Department of Architecture