Dr. Jonathan Cohen

Biography

Jonathan Cohen is an expert in Neurobiology with a focus on ion channel neurotransmitter biology. His research examines how neurons communicate through the release of neurotransmitter molecules such as glutamate, GABA, acetylcholine, dopamine, and serotonin at synapses. By understanding the interactions between neurotransmitters and their receptors, especially GABA receptors which are major inhibitory neurotransmitters, Cohen's work has significant implications for basic neuroscience, particularly in understanding nervous system disorders. His lab specifically investigates the molecular aspects of GABA receptors, which are vital targets for important drugs, including antiepileptics and anesthetics. Current projects aim to define the diversity of general anesthetic binding sites on GABA receptors, contributing to the development of anesthetics with fewer side effects. Cohen also studies nicotinic acetylcholine receptors, which play crucial roles in the regulation of sleep, attention, learning, and memory. Dysfunctions in these receptors are linked to disorders such as Alzheimer’s and Parkinson’s disease, highlighting their potential as therapeutic targets.

Research Interests