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Jonathan Erlich is a Senior Lecturer in the School of Clinical Medicine at the University of New South Wales. His research primarily focuses on cell signaling and the coagulation pathway's contribution to inflammation in various scenarios. Dr. Erlich examines the role of the protease-activated coagulation cascade and its effect on protease-activated receptors, specifically in the context of cardiac and renal ischaemia and reperfusion injury. His recent studies investigate the downstream intracellular signaling pathways associated with PAR-1 signaling. Dr. Erlich aims to define potential therapeutic targets to mitigate renal damage that occurs during renal ischaemia and reperfusion injury (IRI), which is relevant to a wide range of clinical situations including aortic surgery and renal transplantation. He employs mouse models to study the mechanisms by which inhibition of the PAR-1 receptor can protect against renal injury during IRI, thus providing a framework to develop interventions that deliver additive benefits.
University of New South Wales • Sydney
Teaching and conducting research in the Department of Nephrology.
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