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Jonathan Hanley is a Professor of Molecular Neuroscience at the University of Bristol. His research focuses on the molecular mechanisms underlying synaptic plasticity, particularly the role of AMPA receptors (AMPARs) in the brain's excitatory synapses. Hanley's studies employ a range of biochemical and molecular imaging techniques to analyze synaptic function and collaborate with electrophysiologists and behavioral neuroscientists to investigate memory processes. Recent research emphasizes the control of gene expression by microRNA systems and their influence on the regulation of AMPARs at dendritic spines. He has published extensively on the interactions of proteins involved in AMPAR trafficking and dendritic spine morphogenesis. His findings contribute valuable insights into the molecular machinery that governs long-term changes in synaptic efficacy, which are essential for memory formation. Hanley's lab is currently exploring the effects of Argonaute protein phosphorylation on gene silencing in the context of learning and memory, aiming to uncover the connections between RISC dynamics and synaptic structure.
University of Bristol • Bristol, UK
Leading research in Molecular Neuroscience focused on synaptic plasticity and memory.
Department of Physics research themes include Astrophysics, Materials and Devices, Particle Physics, and Quantum and Soft Matter.