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Jonathan Weissman investigates how proteins fold into their correct shapes and the impact of misfolding on disease and normal physiology. He builds innovative tools to explore the organizational principles of biological systems. His research includes ribosome profiling, which globally monitors protein translation, and the use of CRISPRi/a to control the expression of human genes and rewire the epigenome. He also develops lineage tracing tools to record the history of cells.