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Professor Horowitz’s research focuses on developing predictive nonequilibrium frameworks that inform thermodynamic design principles underlying the structure, function, and operation of life. While thermodynamics has achieved remarkable success with theoretical frameworks, it remains limited when it comes to equilibrium situations, especially since the natural world, particularly life, operates far from thermodynamic equilibrium. Cells utilize energy in dramatic ways to carry out a variety of necessary tasks, including intercellular transport and signal transduction for DNA proofreading. Horowitz aims to understand the fundamental perspectives on energy that make these processes possible, investigating universal trade-offs between task and function as they pertain to nonequilibrium thermodynamics. To accomplish this goal, he employs theoretical tools from statistical mechanics, stochastic thermodynamics, and large deviation theory, complemented by numerical modeling.
University of Michigan • Ann Arbor, MI
Teaching and researching in the field of theoretical biological physics and thermodynamics.
Department of Electrical Engineering and Computer Science