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Joriene C. De Nooij is an Assistant Professor at Columbia University within the Neurological Sciences Department, specifically in Neurology. Her research focuses on the molecular and cellular foundations of the proprioceptive sensory system, which is crucial for normal motor behavior. Her work involves delineating the molecular mechanisms underlying the main proprioceptor subtypes and their roles in generating coordinated motor outputs. Through the use of mouse model systems, she employs various molecular and genetic techniques to identify molecules critical for proprioceptor subtype specification and to investigate connectivity patterns within the spinal cord. Furthermore, Joriene is engaged in developing protocols to derive somatic sensory neurons from human embryonic stem cells and induced pluripotent stem cells, aiming to create in vitro model systems for studying sensory neuropathies like Friedreich ataxia and chemotherapy-induced peripheral neuropathy. Her research combines both in vitro and in vivo approaches to enhance the understanding of proprioceptor development and function in both normal and pathological conditions.
Department of Anthropology (GSAS)