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Jose Gabriel Barcia Duran is a Research Instructor in the Department of Medicine, focusing on cardiovascular biology, immunology, and inflammation. His research is centered on understanding the intrinsic non-cell-autonomous processes governing immune cell ontogeny and function in the context of cardiovascular disease. His work has revealed novel cell-extrinsic mechanisms by which immune cells, progenitors, and the vasculature interact, providing tractable platforms for the study of vasculopathies, inflammatory conditions, and cancer. Currently, he is focused on the immune cell function in atherosclerosis, particularly how atherosclerotic plaques form through lipid and immune cell accumulation in artery walls. He investigates the ways in which stable plaques may rupture, leading to serious cardiovascular events such as myocardial infarction and stroke, and explores the involvement of immune cell types, especially macrophages, in resolving inflammatory processes and promoting plaque progression and rupture. His approach utilizes genomic and genetic tools to reconstruct the transcriptional and proteomic landscapes of atherosclerotic plaque leukocytes, with the goal of identifying pro-resolving macrophage signaling networks and developing specific therapeutic interventions.
Open Program in Biomedical Sciences (Vilcek Institute) covers departments like Biochemistry, Pathology, Neuroscience, Microbiology, etc.