Dr. Joseph Baur

Biography

Joseph Baur is a Professor in the Department of Physiology at the Perelman School of Medicine, University of Pennsylvania. His research focuses on the molecular mechanisms of aging and metabolism, emphasizing how nicotinamide adenine dinucleotide (NAD) metabolism and mTOR signaling influence health and longevity. He has explored the functional consequences of changes in NAD metabolism, investigating the effects of NAD precursors like nicotinamide riboside and nicotinamide mononucleotide on health and longevity in animal models. Underlying his work is a commitment to understanding how interventions can delay age-related diseases like cardiovascular disease, diabetes, cancer, and neurodegeneration. Baur collaborates with various researchers to elucidate metabolic pathways and has made significant contributions to the understanding of mitochondrial NAD transport and mTOR signaling pathways. He is also researching the impact of sleep disruption on endocrine function and its association with cognitive decline in Alzheimer’s disease models, demonstrating the critical links between sleep, metabolism, and aging processes. Baur's extensive research and academic work underscore his commitment to pioneering advancements in understanding aging and metabolic health.

Research Interests

Experience