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Joseph Baur is a Professor in the Physiology Department at the Perelman School of Medicine, University of Pennsylvania. His research focuses on understanding the molecular mechanisms of aging and metabolism, particularly the role of nicotinamide adenine dinucleotide (NAD) and mTOR signaling pathways in age-related diseases. He has made significant contributions to elucidating how alterations in NAD metabolism affect health and longevity, particularly in the context of caloric restriction and genetic interventions. His current projects investigate the effects of nicotinamide riboside and nicotinamide mononucleotide on health outcomes, alongside the exploration of mTOR inhibitors to understand their potential in extending lifespan without adverse side effects. Baur collaborates with several institutions to leverage advanced genetic models and tracer studies, fostering innovative approaches to unveil the metabolic pathways related to NAD synthesis and its implications in aging and disease. He also researches the endocrine impacts of sleep disruption on cognitive decline and diabetes.
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