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Joseph Fraietta, Ph.D., is an Assistant Professor in the Department of Microbiology at the Perelman School of Medicine, University of Pennsylvania. His research focuses on innovative immunotherapy strategies that leverage T cells to combat cancer. He aims to enhance the functionality of adoptively transferred T cells through sophisticated genetic engineering approaches, including Next-generation Synthetic Biology and epigenetic modulation. His laboratory has conducted groundbreaking studies in CAR T cell therapy, pioneering the introduction of multiplex CRISPR/Cas9-edited T cells into patients. Dr. Fraietta's work explores how epigenetic programming can improve the efficacy of CAR T cell therapies, particularly in overcoming resistance in non-responsive patients. He directs the Translational Correlative Sciences Laboratory, where he translates laboratory findings into actionable clinical strategies. His efforts contribute significantly to the field of cancer immunotherapy by identifying biomarkers for successful responses to treatment and creating personalized therapeutic approaches.
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