Dr. Joseph Lee

Biography

Joseph H. Lee, DrPH, studies genetic epidemiology of Alzheimer's Disease (AD) and age-related diseases in unique high-risk populations. His research encompasses four primary areas: he and his colleagues study families carrying mutations in the PSEN1 gene that contribute to AD risk, aiming to identify protective genetic and environmental factors that help family members escape AD into late ages. Dr. Lee applies genomic and transcriptomic approaches to examine functional relevance once genetic variants are identified. His team is also exploring the natural history of Alzheimer disease in adults with Down syndrome, who have a heightened risk due to their genetic profile. Moreover, they conduct multi-site longitudinal studies to determine the factors contributing to the health of individuals living to an exceptionally old age. Dr. Lee collaborates with researchers studying a unique inbred American-Indian cohort in Venezuela and investigates environmental exposures and their effects on age-related diseases. His work is well-regarded in the field of genetic epidemiology, particularly concerning healthy aging and longevity.

Research Interests

Experience