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Joseph John Loparo is a Professor at Harvard Medical School, specializing in Biological Chemistry and Molecular Pharmacology. His laboratory focuses on the development and application of single-molecule methods to understand molecular dynamics of multi-protein complexes involved in genome maintenance. Traditional methods have provided insights into individual proteins and collective actions; however, the dynamics of protein-protein interactions remain complex. Loparo's research centers on creating innovative single-molecule tools to study these interactions at physiological concentrations, addressing the challenges posed by high dissociation constants. Major research areas include investigating the structural organization of the replisome during DNA replication, understanding the role of translesion polymerases in DNA repair processes, and the complex architecture of bacterial chromosomes. Notably, his work seeks to elucidate the molecular mechanisms of nucleoid-associated proteins in regulating bacterial chromosome segregation and DNA repair pathways, which have implications for understanding various diseases, including cancer.
Administered by the Division of Medical Sciences (DMS). GRE is not required and will not be considered for BBS, Immunology, and Neuroscience.