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Joseph Mancias is an Associate Professor in the Department of Radiation Oncology at Dana Farber Cancer Institute. His research focuses on pancreatic ductal adenocarcinoma (PDAC), a particularly challenging cancer with a dismal five-year survival rate of only 13%. Mancias's laboratory investigates the roles of autophagy and iron metabolism in PDAC, aiming to define novel therapeutic targets. His team employs mass spectrometry-based quantitative proteomics and patient-derived mouse models to understand the unique dependence of PDAC on autophagy, which plays a critical role in maintaining cellular metabolism and genomic integrity. Through his work, Mancias has pioneered techniques in lysosomal proteomics that allow for in-depth analysis of the proteomic landscape of PDAC tumors and their metastases, leading to insights about how these tumors adapt and evolve. He has also explored the therapeutic implications of targeting the autophagic pathways in PDAC, especially in the context of resistance to KRAS inhibitors.
Dana Farber Cancer Institute • Boston, MA
Research in pancreatic ductal adenocarcinoma focusing on therapeutic targets related to autophagy and iron metabolism.
Administered by the Harvard Kenneth C. Griffin Graduate School of Arts and Sciences (GSAS).