Dr. Joseph St Geme Iii

Biography

Joseph W. St. Geme, III, MD, is a Professor in the Department of Pediatrics at the Perelman School of Medicine at the University of Pennsylvania. His laboratory primarily focuses on understanding the molecular and cellular determinants of bacterial pathogenicity, with a particular emphasis on Haemophilus influenzae and Kingella kingae. His research investigates these common pediatric pathogens and their mechanisms of adherence and colonization, as well as their implications in diseases such as otitis media and sinusitis. The lab employs various methods including genetic approaches, protein chemistry, X-ray crystallography, and high-resolution microscopy to study these mucosal pathogens. Dr. St. Geme aims to elucidate how these pathogens initiate infection, establish commensal states, and transition to disease-causing forms. His work also explores the immunological properties and potential vaccine targets related to the type IV pili and other surface factors critical for pathogen adherence. Furthermore, he studies K. kingae as an emerging cause of serious infections in young children, with ongoing research into how its polysaccharide capsule contributes to its virulence and resistance to host defenses.

Research Interests

Experience