Dr. Joshua Dunaief

Biography

Joshua L. Dunaief, MD, PhD is a leading researcher in the field of ophthalmology with a focus on age-related macular degeneration (AMD), a major cause of irreversible blindness. He has contributed significantly to the understanding of the pathogenesis of AMD, particularly the role of oxidative damage and iron overload in retinal degeneration. His laboratory utilizes advanced mouse models and human retinal tissue to investigate the mechanisms of retinal iron regulation and their implications for therapeutic development. Dunaief's work highlights the complex interplay between inflammation and iron homeostasis in the retina and seeks to develop interventions to protect retinal cells from degeneration. He emphasizes the use of conditional knockout mouse models, immunofluorescence techniques, and various cell culture methods in his research. Dunaief has a distinguished academic background with degrees from Harvard University and Columbia University, where he earned both his MD and PhD. His ongoing research efforts aim to establish a deeper understanding of retinal iron metabolism and to design effective therapies against AMD.

Research Interests