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Joshua L. Dunaief, MD, PhD, is a leading researcher in the field of age-related macular degeneration (AMD) at the University of Pennsylvania's Perelman School of Medicine. His research focuses on the mechanisms and therapeutics behind retinal neurodegeneration, particularly those that contribute to irreversible blindness caused by AMD. Dr. Dunaief has made significant contributions by exploring how oxidative stress, iron transport, and inflammation influence retinal health. His lab employs cutting-edge techniques including conditional knockout mouse models and cell culture to investigate iron homeostasis in retinal cells, aiming to develop effective treatments for AMD. Under his direction, the lab has uncovered critical insights into cellular iron overload and its role in disease progression. His clinical expertise extends to diagnosing and managing AMD, further informing his research pursuits. Dr. Dunaief is dedicated to training the next generation of scientists in this complex field, as evidenced by his mentoring of graduate students and research associates in diverse laboratory projects.
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