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Joshua L. Dunaief holds an MD and a PhD, and is a faculty member in the Department of Ophthalmology at the Perelman School of Medicine, University of Pennsylvania. His research primarily focuses on the mechanisms and therapeutics related to age-related retinal neurodegeneration, particularly age-related macular degeneration (AMD). Dunaief's lab studies how oxidative stress, iron transport, and inflammation contribute to retinal degeneration, employing conditional knockout mouse models and human retinal tissue. Significant findings from his lab include the role of retinal iron overload in AMD pathogenesis and the impact of inflammation on cellular iron levels, establishing a cycle that leads to cell death. His lab aims to advance understanding of retinal iron homeostasis in order to develop protective treatments for the retina.
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