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Juan R. Alvarez is an Assistant Professor in the Department of Cell Developmental Biology at the University of Pennsylvania's Perelman School of Medicine. He obtained his B.A. in Molecular Biology from Princeton University in 2009 and a Ph.D. in Biology from the Massachusetts Institute of Technology in 2015. His research focuses on chronobiology, specifically how biological rhythms affect the functional maturation of differentiated cells. His laboratory utilizes genetic engineering tools to investigate the synchronization and evolution of cell functional states, seeking to understand how circadian metabolic cycles regulate cell maturity. The lab employs a combination of single-cell transcriptomic, epigenomic, and proteomic methods, alongside genetic and nanoelectronics-based approaches, to study and control islet cell fate. Dr. Alvarez aims to advance replacement therapies for insulin-dependent diabetes by leveraging human organoid applications. The research addresses foundational questions regarding the specialization of tissues and the impact of circadian rhythms on organ physiology.
Wharton Doctoral programs cover fields like Finance, Marketing, Management, and Operations, Information and Decisions.