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Judith B. Grinspan is a Research Professor in the Department of Neurology at the University of Pennsylvania. She completed her A.B. in Biology at Vassar College in 1974, followed by an M.S. in Pathology from Hahnemann University in 1977 and a Ph.D. in Biology from the University of Pennsylvania in 1984. Her research focuses on the maturation of oligodendrocytes, the myelinating cells of the central nervous system, and the role of stem cells in myelination. The lab investigates the factors that control the maturation of oligodendrocytes and the impact of demyelination due to various conditions, including multiple sclerosis and HIV. Current projects explore the relationship between white matter loss and HIV-associated neurocognitive deficits and the factors that limit myelination following perinatal white matter injury. The Grinspan lab aims to identify signaling pathways that inhibit the development of mature oligodendrocytes, which could advance therapeutic strategies for demyelinating diseases.
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