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Jueqi Chen is an Assistant Professor at the University of Chicago specializing in the study of inflammasomes, which are multi-protein complexes responsible for the induction of proinflammatory cytokines and inflammatory cell death. His research lab focuses on dissecting the molecular mechanisms of inflammasome pathways and investigating how dysfunction in these pathways can lead to defective host defense against pathogenic microorganisms, as well as impact various conditions such as autoimmune diseases, neurodegeneration, and metabolic syndromes. The lab employs diverse approaches including biochemical assays, confocal fluorescence imaging, and CRISPR knockout/rescue animal models. Recently, Chen's research has uncovered an unexpected role of trans-Golgi network dispersion in inflammasome activation. He is currently interested in studying how certain pathogens can evade and hijack cellular signaling to counter host defenses, with the aim of unveiling potential therapeutic targets for infectious diseases and improving human health.
UT Southwestern Medical Center • Dallas, TX
Conducted research in immunology and microbiology.
Department of Philosophy