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Dr. McElrath's laboratory research focuses on the identification and characterization of cellular immune responses that provide protection against HIV infection and disease. Her studies entail understanding the immune responses of individuals who demonstrate unique control over the infection, through cohort studies in Seattle and internationally. A major aspect of her studies is to apply the mechanisms of HIV control to HIV vaccine development. Additional projects include immune correlates research for TB and malaria vaccine development. Current investigations examine components of T cell immunity elicited during early HIV-1 infection that contribute to the control of HIV-1 disease. Moreover, Dr. McElrath explores the role of T cell immune responses in resistance to HIV-1 infection among individuals repeatedly exposed to the virus through sexual contact. Other focused areas include the contribution of antigen-specific mucosal T cells in providing protection against HIV-1 exposure, as well as how innate immunity can improve vaccine design. Her research is conducted in collaboration with a number of prominent researchers in the field.
Vaccine & Infectious Disease Division, Fred Hutchinson Cancer Research Center • Seattle, WA
Oversees research and development in the field of infectious diseases and vaccines.
Fred Hutch provides training for many UW-affiliated PhD programs. This entry covers the interdisciplinary Molecular and Cellular Biology (MCB) program which encompasses departments like Biology, Medicine, and Human Biology.