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Julien Muffat is an Assistant Professor in the Department of Molecular Genetics at the University of Toronto. His research focuses on understanding the genetic and environmental vulnerabilities that contribute to neurological disorders. His work primarily uses novel 3D cultures derived from human induced pluripotent stem cells (iPSCs) to study degenerative diseases of the brain, with particular attention to inflammatory triggers and viral aetiologies associated with conditions such as Autism, Multiple Sclerosis, and Alzheimer's disease. Muffat’s lab employs a CRISPR toolkit for functional interrogation of disease-associated variants, expressed in specific cell types, and conducts unbiased genome-wide screens to explore cellular resilience states. He holds a Canada Research Chair in Synthetic Neuroimmunology and Stem Cell Bioengineering, underscoring his commitment to advancing our understanding of the molecular mechanisms underlying these complex diseases.
University of Toronto • Toronto, Ontario, Canada
Teaches and conducts research in the field of Molecular Genetics with a focus on neurological disorders.
Department of Sociology