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Junwei Shi, Ph.D., is an Associate Professor in the Cancer Biology Department at the Perelman School of Medicine, University of Pennsylvania. His research focuses on the physiological effects of cancer manifestation and the genetic abnormalities that cause disease. His lab utilizes CRISPR gene-editing technology to investigate genetic perturbations that contribute to cancer maintenance, primarily exploring the functional importance of epigenetic regulators in leukemia. Shi's team aims to identify and treat cancer-causing mutations, leveraging whole exome sequencing to reveal oncogene mutations and providing actionable therapeutic opportunities. Current projects involve the development of optimized multiplex genetic dropout screening methods, aiming to uncover complex genetic interactions in leukemia that are therapeutically tractable. Shi employs a combination of functional genomics screening, biochemical assays, and pre-clinical mouse models to investigate aberrant transcription signaling networks and potential therapeutic targets in cancer. His work seeks to enhance the understanding of genetic vulnerabilities in leukemia and optimize screening tools for better evaluation of protein domains as drug targets.
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