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Junwei Shi is an Associate Professor in the Department of Cancer Biology at the Perelman School of Medicine, University of Pennsylvania. He completed his B.S. in Biotechnology at Sun Yat-sen University in China in 2008 and obtained his Ph.D. in Molecular Cellular Biology from Stony Brook University, SUNY, in 2016. His research expertise focuses on understanding the physiological effects of cancer manifestation driven by genetic abnormalities. Shi's lab has made significant progress in understanding the genetic perturbations that contribute to cancer maintenance while addressing the rapid evolution of the disease and the accumulation of novel mutations that allow cells to survive in therapeutic environments. His current research includes defining the functional importance of epigenetic regulators in leukemia, optimizing AsCas12a multiplex genetic dropout screening, and developing new functional genomic tools. The lab employs CRISPR gene-editing technology to introduce mutations at target loci, aiming to uncover complex genetic interactions and therapeutic targets in leukemia. Shi's work emphasizes high-throughput identification of critical protein domains as potential drug targets, alongside biochemical assays and pre-clinical mouse models to further explore therapeutic opportunities.
Wharton Doctoral programs cover fields like Finance, Marketing, Management, and Operations, Information and Decisions.