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Kai Tan is a Professor in the Department of Pediatrics at the Perelman School of Medicine, University of Pennsylvania. His research expertise lies in gene regulation and its essential role in cellular development and cancer. His lab employs genomics and systems biology approaches to understand the gene regulatory factors that underlie various cellular processes. They use advanced techniques including bulk and single-cell omics, imaging assays, and develop computational algorithms to integrate data and generate testable models of gene regulatory pathways in model systems. Current projects include creating a multi-omic atlas of pediatric cancer, identifying novel combination therapies by mapping disease-perturbed gene networks, and investigating how continuously adapting cancer cells respond to targeted therapies and immunotherapies. His work also delves into gene regulatory networks controlling embryonic hematopoietic stem cell origin and T-cell differentiation. Notable research questions encompass the key regulators affecting gene expression, the impact of genome organization, and the role of signaling pathways in cellular communication, utilizing high-dimensional single-cell transcriptomics and integration of multi-omics data in a data-driven manner.
Wharton Doctoral programs cover fields like Finance, Marketing, Management, and Operations, Information and Decisions.