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Kara Anne Bernstein is a researcher and professor specializing in the molecular aspects of cancer development, particularly in the context of breast and ovarian cancers. Her research primarily focuses on the role of DNA repair proteins in the accurate repair of DNA double-strand breaks, which are critical for maintaining genomic stability. Using both budding yeast and mammalian systems, her lab investigates the functional significance of RAD51 paralogs and their implicated mutated forms in hereditary breast and ovarian cancer. She employs genetic, biochemical, and cell biology techniques to uncover how these genes impact cancer risk, especially when compounded by environmental toxicants. Bernstein's work aims to identify individuals at increased risk for cancer based on their genetic profile and family history, and she leads laboratories focused on dissecting the mechanisms of cancer development related to the misregulation of DNA repair pathways.
University of Pennsylvania • Philadelphia, PA
Teaching and conducting research in the field of biochemistry and biophysics, with a focus on cancer development and DNA repair mechanisms.
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