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Kareen L K Coulombe is an Associate Professor specializing in cardiovascular regenerative engineering. Her research addresses global needs for developing novel therapies to mitigate the consequences of heart attacks and assess cardiotoxicity. A key focus of her work is re-engineering heart contractility in the context of myocardial infarction by utilizing engineered human myocardium and cardiomyocytes derived from human induced pluripotent stem cells. Her laboratory investigates the complex biological processes underlying the electromechanical function of heart tissue and aims to predict toxicity through the integration of electrical and neovascular development in the heart. Dr. Coulombe earned her B.S. in Biomedical Engineering from the University of Rochester, graduating summa cum laude in 2001, and completed her Ph.D. in Bioengineering at the University of Washington in 2007 as a Whitaker Predoctoral Fellow. She was subsequently an NIH Ruth L. Kirschstein postdoctoral fellow in Pathology at the University of Washington, where she was awarded the NIH Pathway to Independence K99/R00 award in 2012. Since joining Brown University in January 2014, she has contributed to advancements in heart regeneration and health through various funded research projects. Her lab employs engineering, biomaterials, stem cell biology, and imaging technologies to enhance the understanding of heart tissue development and functionality, with the long-term goal of advancing therapeutic approaches for heart regeneration.
Brown University • Providence, RI
Dr. Coulombe specializes in cardiovascular regenerative engineering, focusing on developing therapeutic strategies for heart disease.
Department: Department of Economics