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Karen Adelman is a leading researcher in the field of Biological Chemistry and Molecular Pharmacology. Her laboratory focuses on the dynamic interplay of signals from the environment and transcription by RNA polymerase II (Pol II). Since receiving her Ph.D. from Universite de Paris VI in 1999, she has made significant contributions to understanding how cells integrate multiple intracellular and extracellular cues to produce specific patterns of gene expression. Her research at Harvard Medical School explores the mechanisms by which gene networks are activated in response to environmental stimuli, employing genomic approaches and model systems like Drosophila and murine models. Adelman's group is particularly known for pioneering global studies of Pol II pausing during early transcription elongation, a central aspect of gene regulation in metazoans. Her work has revealed crucial insights into how Pol II pausing influences gene activity and chromatin structure, providing a deeper understanding of gene-environment interactions and their implications in disease etiology, including chronic inflammation and cancer. Ongoing investigations aim to elucidate further the role of pausing in transcriptional dynamics during development and differentiation.
Harvard Medical School • Boston, MA
Joined the faculty of Harvard Medical School as a Professor in the Department of Biological Chemistry and Molecular Pharmacology.
National Institute of Environmental Health Sciences (NIH) •
Established her own laboratory focusing on gene regulation and environmental responses.
Administered by the Division of Medical Sciences (DMS). GRE is not required and will not be considered for BBS, Immunology, and Neuroscience.