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Karen Oegema received her PhD in Cell Biology from the University of California, San Francisco, and conducted postdoctoral work at the European Molecular Biology Laboratory in Heidelberg and the Max Planck Institute for Cell Biology & Genetics in Dresden. Her lab focuses on the interface between cell and cancer biology with a long-term interest in the molecular machinery underlying mitosis and cytokinesis. Recent research revealed significant variations in cell-type-specific cell division accomplished through distinct mechanisms. A major current focus is to determine differences leveraged to induce cell death due to aberrant mitosis, advancing chemotherapeutic strategies. Notably, her work on centrosomes has explored the therapeutic potential of centrosome removal in cancer, collaborating with the Small Molecule Discovery Group at the Ludwig Institute for Cancer Research to develop a Plk4 inhibitor. The lab also aims to generate a phenotypic map of genes essential for embryonic development in the model organism C. elegans, employing high-content approaches based on time-lapse imaging to understand tissue specification and morphogenesis during embryogenesis.
University of California, San Diego • La Jolla, CA
Leading research in cell and cancer biology, focusing on molecular machinery underlying mitosis and cytokinesis.
Administered by the Scripps Institution of Oceanography. Curricular groups include Climate-Ocean-Atmosphere (COAP), Geosciences (GEO), and Ocean Biosciences (OBP).