Dr. Karl Dimiter Bissig

Biography

Karl-Dimiter Bissig is an associate professor in the Department of Pediatrics at Duke University and holds additional appointments in Biomedical Engineering and Pharmacology Cancer Biology. His work primarily focuses on investigating diseases of the liver, including viral hepatitis, metabolic liver disorders, and liver cancer. Bissig's laboratory specializes in creating human liver chimeric mice, which serve as novel patient-derived cancer models and xenograft models for metabolic liver disease. His innovative research employs humanized mouse models to develop new therapeutic approaches, leveraging CRISPR-based gene therapy techniques for metabolic pathway reprogramming. He completed his postdoctoral fellowship at the Salk Institute for Biological Studies and has an MD/PhD from the University of Bern, Switzerland. He has been awarded multiple grants from institutions such as the National Institutes of Health and the National Institute of Diabetes and Digestive and Kidney Diseases, reflecting his ongoing contribution to medical genetics and genomics. Bissig has authored numerous publications and teaches various courses related to biomedical engineering and pharmacology at the university.

Research Interests

Courses