Dr. Karlene Cimprich

Biography

Karlene Cimprich is a Professor of Chemical Systems Biology at Stanford University, holding a courtesy appointment in the Department of Biochemistry. Her research focuses on genomic stability and its relation to diseases, particularly cancer and neurodegenerative disorders. Cimprich's laboratory investigates how cells maintain genomic stability, specifically through the DNA damage response (DDR) mechanisms. Important aspects of her work include understanding the processes involved when DNA replication encounters damage and the strategies cells utilize to manage and repair this damage. Her interest extends to the signaling pathways that initiate DDR and how they interact with DNA replication to ensure cellular integrity. The lab employs a variety of techniques using cultured mammalian cells and frog egg extracts. Additionally, Cimprich has identified new factors involved in DDR processes and is currently exploring their significance in various health contexts, particularly how they relate to kidney diseases and genomic maintenance. Throughout her career, she has received multiple prestigious awards, including the Kimmel Scholar Award and the American Cancer Society Research Professor title. In addition to her research, Cimprich is actively involved in teaching various courses related to chemical systems biology.

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