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The Gallo laboratory is focused on understanding the therapeutic targeting of signaling pathways that govern cancer progression. The research is particularly focused on the roles of the mixed-lineage kinase (MLK) family in cancer invasion and metastasis, with a specific emphasis on breast cancer. Recent studies have demonstrated the critical role of MLK3 in promoting metastasis of triple-negative breast cancer through the regulation of focal adhesion turnover, cell migration, and gene expression related to invasion and metastasis. Additionally, the lab studies the roles of MLK family members in signaling pathways associated with lung cancer, glioblastoma, and melanoma. The laboratory employs a variety of approaches and techniques to investigate the mechanisms underlying tumor proliferation, invasion, and metastatic outgrowth, utilizing 3D organotypic assays, cell biology, animal models, mass spectrometry, and biochemical techniques. The Gallo lab collaborates with the Conrad lab in Microbiology & Molecular Genetics to identify mechanisms for alternative therapeutic strategies in endocrine-resistant breast cancer, and with the Neubig lab in Pharmacology & Toxicology to explore effective combination therapies for drug-resistant melanoma.
Department of Psychology