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Kathryn E. Wellen is a Professor in the Department of Cancer Biology at the University of Pennsylvania's Perelman School of Medicine. Her research focuses on cellular metabolism and its regulation of signal transduction, gene expression, and metabolic diseases such as cancer and diabetes. Wellen's lab investigates how cancer cells alter nutrient uptake and metabolism to enhance their growth and division. She examines the impact of nutrient-sensitive protein modifications on signaling and gene expression in the context of cancer. A key area of her research explores how the hexosamine biosynthetic pathway regulates metabolism and growth in cancer cells, impacting glycosylation of proteins and their interactions with the environment. Wellen's work employs various cellular models and mouse models to elucidate these mechanisms, aiming to better understand the metabolic reprogramming of cancer cells and its potential therapeutic implications.
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