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Kefei Yu is a Professor at Michigan State University's College of Natural Science, specializing in the study of DNA recombination and DNA repair in immune cells. His research focuses on mechanisms associated with antigen receptor gene diversification, including site-directed V(D)J recombination which assembles immunoglobulin antigen binding domains and T cell receptor genes. His lab investigates critical processes such as class switch recombination (CSR), which enables immunoglobulin isotype switching. Yu's work also addresses the impact of CSR on genomic stability, with an emphasis on the consequences of dysregulated CSR, including hyper-IgM syndrome and oncogenic chromosomal translocations in B cell lymphomas. He is engaged in exploring the roles of somatic hypermutation (SHM) and the enzyme activation-induced cytidine deaminase (AID) in these processes. Yu holds a B.S. in Biochemistry from Nanjing University and a Ph.D. in Microbiology Molecular Immunology from the University of Southern California. He has extensive experience as a Research Associate at the Norris Cancer Center before joining the faculty at Michigan State University.
Norris Cancer Center, University of Southern California • Los Angeles, CA
Conducted research on DNA recombination and DNA repair mechanisms in immune cells.
Department of Psychology