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Keir Menzies is a molecular biologist with a strong interest in aging and metabolism, particularly in relation to cellular NAD+ homeostasis. He received his MSc and PhD degrees from the Muscle Health Research Centre at York University under the supervision of Dr. David Hood, who is a Canada Research Chair specializing in exercise physiology. Menzies obtained his HBSc in biological chemistry from the University of Toronto. His training has contributed to significant insights into the role of mitochondria and oxidative stress in skeletal muscle aging and the effects of disuse and exercise. His research has involved a variety of metabolism-related topics, including the role of sirtuin proteins as regulators of mitochondrial function in muscle during aging and exercise. Further work in the field of sirtuins led him to receive the Article of the Year award from the Journal of Biological Chemistry. Menzies also completed his postdoctoral training with Dr. Johan Auwerx, the Nestle Chair in Energy Metabolism at the École Polytechnique Fédérale de Lausanne, where he was recognized as one of the 400 influential biomedical researchers by the European Journal of Clinical Investigation in 2013. His time in Switzerland allowed him to gain expertise in sirtuin signaling, NAD+ metabolism, and genetics in various models including roundworms, mice, and humans. Currently, Professor Menzies is undertaking an integrated systems physiology approach to examine signaling mechanisms and develop translational methodologies aimed at discovering new treatment strategies and biomarkers for metabolic disorders and age-related diseases.
Department of History