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Dr. Kelly L. Jordan-Sciutto is a faculty member at the Perelman School of Medicine at the University of Pennsylvania, specializing in the study of neuroinflammation and neurodegenerative disorders. Her research focuses on the signaling pathways involved in responses to neuroinflammatory stimuli, particularly in the context of diseases such as HIV, Alzheimer's Disease, and Parkinson's Disease. She employs various experimental approaches to investigate the molecular mechanisms of neuronal loss and neuroprotection, with a particular interest in organellar stress communication among key cell types in the central nervous system, including neurons, oligodendrocytes, microglia, and astrocytes. Her laboratory also examines the role of genetic variants, particularly in the Protein Kinase R-like endoplasmic reticulum kinase (PERK) pathway, in cognitive and behavioral outcomes in individuals affected by HIV. Additionally, Dr. Jordan-Sciutto is interested in enhancing endogenous antioxidant responses as a therapeutic strategy for preventing neuronal damage in neurodegenerative conditions.
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