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Kenneth N. Kreuzer is a Professor Emeritus in the Department of Biochemistry at Duke University. His research focuses on the molecular mechanisms of DNA replication, recombination, and repair, utilizing bacteriophage T4 and Escherichia coli as model systems. His projects involve investigating the molecular mechanism of phage T4 origin-dependent DNA replication and the role of RNA-DNA hybrids (R loops) in this process. He has extensively studied the implications of replication fork failure, particularly in cases where DNA damage leads to fork breakage, and has examined the role of homologous recombination in repairing broken replication forks. His recent research has provided insights into the function of the Mre11-Rad50 complex in double-strand break repair, and he has explored the cytotoxic effects of type II DNA topoisomerase inhibitors, which are relevant in cancer treatment. Additionally, he has investigated the physiological roles of DNA helicases, particularly in relation to Bloom's and Werner's syndromes. In collaboration with Dr. Stephen White of St. Jude Children's Research Hospital, he is analyzing the structure and function of the UvsW helicase in phage recombination and repair processes.
Department of Biomedical Engineering (MS program)