Dr. Kenneth Polonsky

Biography

Kenneth S. Polonsky, MD, is the Richard T. Crane Distinguished Service Professor of Medicine at the University of Chicago. His laboratory focuses on the role of abnormal insulin secretion in the pathogenesis of type 2 diabetes. The research utilizes mouse models to investigate the underlying mechanisms of pancreatic β-cell dysfunction. A central area of interest is pancreatic β-cell death, which significantly contributes to the reduction of insulin secretion seen in diabetes. Using the Pdx1 deficiency experimental model, Polonsky’s lab has demonstrated that major forms of programmed cell death—autophagy, apoptosis, and programmed necrosis—contribute to the loss of β-cell mass. Current efforts are directed towards identifying novel strategies to interrupt cell death pathways, particularly focusing on BH3-only proteins Puma and Bim, which mediate β-cell apoptosis. Studies have shown that reducing the expression of Puma and Bim decreases pancreatic β-cell apoptosis in models of diabetes, resulting in improved insulin secretion, increased β-cell mass, and reduced blood glucose levels. His work aims to uncover mechanisms to preserve β-cell function and mass, offering potential therapeutic strategies for the treatment of type 2 diabetes.

Research Interests

Experience

Awards