Dr. Khalid Shah

Biography

Khalid Shah is a Professor at Harvard Medical School and the Vice Chair of Research at the Department of Neurosurgery, Brigham and Women's Hospital. He serves as the Director of the Center for Stem Cell Translational Immunotherapy. His research focuses on developing and testing novel targeted cell-based therapies for brain cancers, a significant challenge in oncology. His laboratory explores the therapeutic potential of various cell types and their integration into mammalian brain transplantation, which has opened new possibilities in this field. Khalid has shown that stem cells can home to sites of cerebral pathology, delivering therapeutic proteins and oncolytic viruses to target tumor cells and modulate the tumor microenvironment. His work includes creating clinically translatable models of primary, recurrent, and metastatic brain tumors, emphasizing engineered stem cells that can release therapeutic proteins to induce cell death and inhibit tumor proliferation. One notable achievement is the development of immunomodulatory stem cells that enhance the efficacy of tumor debulking and subsequent treatments. Khalid's research demonstrates the potential of engineered tumor cells in cancer therapy, which not only target tumors effectively but also stimulate immunological responses. He is committed to transforming these laboratory discoveries into practical therapies that improve the quality of life for cancer patients.

Research Interests