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The Kingston Lab at Harvard University focuses on understanding the mechanisms by which eukaryotic protein complexes regulate the epigenetic status of chromatin in both in vitro and in vivo environments. The lab's main research objectives include isolating chromatin-modifying complexes that are involved in the stable heritable repression and activation of master regulatory genes. This involves utilizing functional assays to test mechanistic hypotheses generated from cell culture and mouse systems. The research emphasizes the dynamic nature of DNA regulation and the structural alterations of chromatin, particularly how nucleosomes, the fundamental units of chromatin, can undergo conformational changes that influence gene expression. The Kingston Lab seeks to determine the functions of these chromatin complexes in the development of specific mammalian cell lineages, exploring the roles of various protein complexes such as Polycomb and trithorax groups in transcriptional regulation and chromatin compaction.
Administered by the Harvard Kenneth C. Griffin Graduate School of Arts and Sciences (GSAS).