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Dr. Kaestner’s lab employs modern genetic and genomic approaches to understand molecular mechanisms of organogenesis and physiology in the liver, pancreas, and gastrointestinal tract. His research includes targets related to diabetes and cancer. The lab focuses on regenerative medicine, particularly strategies for increasing functional beta-cell mass and understanding age-related declines in beta-cell function. Dr. Kaestner's work also explores the role of telocytes in gastrointestinal stem cell niches and the liver’s response to toxic injury, with an aim to develop clinical treatments for chronic liver disease. By analyzing complex epigenomic datasets and utilizing innovative genetic techniques, the lab aims to enhance understanding of these biological processes and translate findings into clinical applications.
Diabetes Research Center, University of Pennsylvania • Philadelphia, PA
Overseeing diabetes research initiatives and coordinating related studies.
Wharton Doctoral programs cover fields like Finance, Marketing, Management, and Operations, Information and Decisions.