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Konrad Hochedlinger is a principal faculty member at the Harvard Stem Cell Institute and an affiliated researcher at the Massachusetts General Hospital and the Broad Institute. His research focuses on the role stem cells play in normal development and disease. The Hochedlinger Lab investigates stem cells' dual potential for self-renewal and the generation of mature cells, which are crucial for development, tissue homeostasis, and injury response in adults. Furthermore, the lab explores the theoretical implications of stem cells in cancer origin and development. His specific interest lies in understanding embryonic stem (ES) cells that are derived from early embryos and their unique ability to differentiate into various cell types—termed pluripotency. His research aims to characterize the factors influencing the balance between self-renewal and differentiation. The lab employs advanced methodologies such as gene targeting, mouse transgenesis, and nuclear transfer to address critical questions surrounding stem cell behavior, with an overarching goal of devising novel strategies for regenerative medicine and effective cancer treatment.
Harvard Stem Cell Institute • Cambridge, MA
Leader of research focused on the roles of stem cells in development and disease, employing advanced methodologies to explore pluripotency and cancer origins.
Administered by the Harvard Kenneth C. Griffin Graduate School of Arts and Sciences (GSAS).