Dr. Koseki Kobayashi Kirschvink

Biography

Koseki Kobayashi-Kirschvink leads an interdisciplinary research group at the University of Chicago that integrates physics, machine learning, and genomics to investigate dynamic biological processes at single-cell resolution. His lab develops new optical molecular tools that reveal how cells self-organize into complex multicellular structures, such as embryos and tissues, and elucidate immune cell function within the tumor microenvironment. The group is particularly focused on a "live-cell omics" approach that measures genome-wide expression in living single cells, which is impossible with conventional omics methods. Their methods enable longitudinal tracking of genomic changes within individual cells, illuminating the molecular mechanisms of cell fate determination and disease progression. The lab also builds next-generation, label-free microscopes that reduce the long acquisition times seen with conventional instruments, opening new possibilities for large-scale studies of molecular dynamics in vitro and in vivo.

Research Interests

Experience