Dr. Koseki Kobayashi Kirschvink

Biography

Dr. Kobayashi leads an interdisciplinary research group that integrates physics, machine learning, and genomics to investigate dynamic biological processes at single-cell resolution. The lab develops new optical molecular tools to reveal how cells self-organize into complex multicellular structures, such as embryos and tissues, and to elucidate immune cell function in the tumor microenvironment. The group is particularly focused on a 'live-cell omics' approach, which measures genome-wide expression in living single cells, a task impossible with conventional omics methods. These methods enable longitudinal tracking of genomic changes in individual cells, illuminating molecular mechanisms of cell-fate determination and disease progression. The lab is also building next-generation, label-free microscopes to reduce the long acquisition times associated with conventional instruments, opening new possibilities for large-scale studies of molecular dynamics in vitro and in vivo.

Research Interests

Experience