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Kristen W. Lynch is a prominent faculty member at the Perelman School of Medicine at the University of Pennsylvania, where she holds the title of Benjamin Rush Professor in the Department of Biochemistry and Biophysics. Her research expertise primarily focuses on the mechanisms and consequences of alternative RNA processing, with significant contributions to understanding human immune responses. Lynch's lab investigates the biochemical mechanisms and regulatory networks that govern RNA processing events within the immune system. A major aspect of her work includes studying RNA binding proteins and their role in post-transcriptional regulation. She has identified multiple kinase pathways that affect the abundance and activity of these proteins in a signal-dependent manner. In the context of cancer, her research has revealed how dysregulated splicing can mimic genetic mutations in leukemia, opening avenues for therapeutic intervention. Additionally, her studies are expanding to explore mechanisms of RNA regulation and their interplay with mRNA decay and translation.
University of California, San Francisco •
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