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Dr. Kristen Lynch is the Benjamin Rush Professor in the Department of Biochemistry and Biophysics at the University of Pennsylvania. She holds a B.A. from Harvard University (1990) and a Ph.D. from Harvard University (1996). Dr. Lynch's research specializes in the mechanisms and consequences of alternative RNA processing and the human immune response. Her laboratory investigates the biochemical mechanisms and regulatory networks that control RNA processing events in the human immune system, focusing on RNA binding proteins, alternative splicing, and alternative polyadenylation. They have uncovered various kinase pathways and post-transcriptional mechanisms that regulate RNA binding proteins in a signal-dependent manner. Additionally, Dr. Lynch's work has implications in cancer research, revealing how dysregulated splicing can mimic genetic mutations in leukemia. Through her studies, the lab is expanding the analysis of RNA regulation, linking it to functional responses within the immune system and exploring potential therapeutic avenues.
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