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Kun Yang is an Assistant Professor at the College of Pharmacy, focusing on the study of DNA-protein cross-links (DPCs) and their biological implications. His research utilizes a combination of biochemistry, molecular and cellular biology, organic synthesis, and mass spectrometry to investigate the sources and effects of DPCs, which are highly cytotoxic mutagenic DNA damages induced by a variety of agents, including ionizing radiation and common anticancer drugs. Yang's work aims to expand the fundamental understanding of the biological effects and repair mechanisms associated with DPCs and ultimately develop strategies to inhibit DPC repair in the context of cancer therapy. His current research projects include the chemical synthesis of biologically relevant DPCs, understanding their biological effects, investigating the molecular mechanisms of DPC repair, and targeting these repair processes with small molecule inhibitors. Yang actively seeks motivated postdoctoral fellows, graduate, and undergraduate students with interests and expertise in the fields of biochemistry and molecular biology to join his research group.
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