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Kuo-Fen Lee is a Professor at the Salk Institute for Biological Studies, where he works in the Clayton Foundation Laboratories focusing on Peptide Biology. He holds the Helen McLoraine Chair in Molecular Neurobiology. Lee's research seeks to understand the mechanisms behind neurodegenerative diseases such as Alzheimer's and Parkinson's. His significant contributions include the discovery of how stress and anxiety-inducing hormones lead to tau protein modifications, which are critical in the pathology of Alzheimer's disease. Lee employs artificial intelligence to detect behavioral deficits and identify selectively vulnerable cell types at the predementia stage of Alzheimer's. His work integrates functional genomics across multiple species to untangle complex interactions influencing brain health and aging. Through these efforts, Lee aims to develop innovative therapeutic strategies for promoting healthier aging and preventing age-related diseases.